The soundtrack album features original songs by Norah Jones, Fiona Apple, Graham Parker, and Lindsey Buckingham all produced by Jon Brion, as well as new tracks from Wilco and Ryan Adams created specifically for the film. Punch Brothers appear as the backing band on several tracks.

In addition, the album also features Paul Simon, Loudon Wainwright, Yoko Ono, and The Avett Brothers. The soundtrack album was produced by Judd Apatow and Jonathan Karp and features songs produced by the film's composer Jon Brion.

Five years after Apatow introduced us to Pete and Debbie in Knocked Up, Paul Rudd and Leslie Mann reprise their roles as a husband and wife both approaching a milestone meltdown in This Is 40, an unfiltered, comedic look inside the life of an American family.

In his fourth directorial outing, Apatow's new comedy captures what it takes for them to flourish in the middle of a lifetime together. The cast also includes John Lithgow, Megan Fox, Iris Apatow, Maude Apatow, Melissa McCarthy, Jason Segel, Robert Smigel, Charlyne Yi and Albert Brooks.

The track listing for Music From The Motion Picture This Is 40 is as follows:

1. I'm Your Angel – Yoko Ono
2. Always Judging – Norah Jones
3. What Do You Like? – Graham Parker with Punch Brothers
4. Sick Of You – Lindsey Buckingham
5. Rewrite – Paul Simon
6. Shining Through The Dark (Live) – Ryan Adams
7. Lunch Box Odd Sox – Paul McCartney
8. Brother & Sister – Lindsey Buckingham Featuring Norah Jones
9. Theme 1 (Debbie & Oliver) – Jon Brion
10. Watch The Moon Come Down – Graham Parker & The Rumour
11. Days That We Die – Loudon Wainwright
12. She Acts Like You – Lindsey Buckingham
13. Dull Tool – Fiona Apple
14. Lucky Now (Live) – Ryan Adams
15. I Got You – Wilco
16. Live & Die – The Avett Brothers